NSAIDs are among the most often prescribed pain relievers. NSAIDs are a highly successful medicine class for pain and inflammation due to the everincreasing number of medications and drug combinations on the market necessitates the development of analytical tools for monitoring their quality. The procedures must be developed in such a way that they take less time to design and produce the most accurate and robust results possible. Omeprazole, a widely used proton pump inhibitor (PPI), has become a cornerstone in the treatment of various acid-related gastrointestinal disorders such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. By inhibiting the proton pump in parietal cells, omeprazole effectively reduces gastric acid secretion, thereby promoting healing and alleviating symptoms associated with hyperacidity.