The rise of multidrug-resistant (MDR) microorganisms has driven the search for novel plant-derived antimicrobial agents.This study evaluated the in vitro antimicrobial potential of Caesalpinia pulcherrima leaf and Zingiber officinale rhizome extracts, individually and in combination, against pathogenic bacteria, Escherichia coli and Staphylococcus aureus.Phytochemical screening confirmed the presence of flavonoids, tannins, saponins, glycosides, phenols, triterpenoids, proteins, and reducing sugars in both the extracts.Using agar disc diffusion and minimum inhibitory concentration (MIC) assays, the combination of both extracts demonstrated synergistic activity, yielding larger zones of inhibition and lower MIC values than those of the individual extracts, approaching the efficacy of ciprofloxacin.These findings suggest that the combined plant extracts could serve as promising candidates for novel antimicrobial therapies.