Believing in the God who created the universe and purposefully gave existence to man and that man was not created by accident, causes a purposeful attitude towards human creation and creates hope in human life. Since man is the highest divine creation, understanding this level together with the fact that his creation is not futile, gives a sufficient attitude to have mental health. Therefore, the purpose of this article is to examine self-knowledge and God-knowledge to have mental health. The present article was compiled with a review and qualitative method, which was inferred from Islamic texts, as well as the works of Islamic thinkers and some psychological sources. Man has received the basis of his existence from the wise creator. This look is the source of mental peace and meeting all his needs. Because cause and effect are not separate from each other. Therefore, the necessary attitude to have mental health is to understand the dependence of man on the creator and the reason for his existence.